Design and Optimization of Plug Flow Crystallizers
نویسندگان
چکیده
This study presents the development of a plug flow crystallization (PFC) platform consisting of a vortex mixer combined with a tubular reactor. Process analytical technologies (FBRM, PVM, FT-IR) were applied in-situ in order to characterize and optimize crystallizations via the use of novel flow cells. In addition to this a new calibration free method for concentration monitoring was successfully utilized. These techniques permit significant reductions in process development time and could facilitate the inclusion of continuous crystallizer configurations in current pharmaceutical commercialization procedures.
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